Round: 1
| NCAAF | 2021/11/06 16:00 | Seton Hill Griffins v Iup Crimson Hawks | W | 3-38 |
| NCAAF | 2019/11/02 16:00 | Seton Hill Griffins v Iup Crimson Hawks | W | 23-50 |
| NCAAF | 2018/10/27 16:00 | Iup Crimson Hawks v Seton Hill Griffins | W | 56-14 |
| NCAAF | 2021/11/13 17:00 | West Chester Golden Rams v Iup Crimson Hawks | W | 24-31 |
| NCAAF | 2021/11/06 16:00 | Seton Hill Griffins v Iup Crimson Hawks | W | 3-38 |
| NCAAF | 2021/10/30 18:00 | Iup Crimson Hawks v Edinboro | L | 17-21 |
| NCAAF | 2021/10/23 18:00 | Iup Crimson Hawks v California Vulcans | L | 34-38 |
| NCAAF | 2021/10/16 17:00 | Slippery Rock v Iup Crimson Hawks | W | 21-48 |
| NCAAF | 2021/10/09 18:00 | Clarion Golden Eagles v Iup Crimson Hawks | W | 21-58 |
| NCAAF | 2021/10/02 18:00 | Iup Crimson Hawks v Gannon University Golden Knights | W | 28-23 |
| NCAAF | 2021/09/25 17:00 | Mercyhurst v Iup Crimson Hawks | W | 13-48 |
| NCAAF | 2021/11/13 18:00 | Lock Haven v Seton Hill Griffins | W | 7-59 |
| NCAAF | 2021/11/06 16:00 | Seton Hill Griffins v Iup Crimson Hawks | L | 3-38 |
| NCAAF | 2021/10/30 20:00 | California Vulcans v Seton Hill Griffins | L | 42-14 |
| NCAAF | 2021/10/23 16:00 | Clarion Golden Eagles v Seton Hill Griffins | W | 0-49 |
| NCAAF | 2021/10/16 20:00 | Seton Hill Griffins v Gannon University Golden Knights | L | 10-14 |
| NCAAF | 2021/10/09 16:00 | Mercyhurst v Seton Hill Griffins | W | 17-19 |
| NCAAF | 2021/10/02 20:00 | Seton Hill Griffins v Edinboro | L | 7-17 |
| NCAAF | 2021/09/25 22:00 | Seton Hill Griffins v Slippery Rock | L | 17-41 |