Stadium: Enmarket Arena
Home Manager: Richie Riley Away Manager: Pat Skerry
| NCAAB | 2022/03/29 00:00 | Coastal Carolina v South Alabama | L | 69-68 |
| NCAAB | 2022/03/22 00:00 | USC Upstate v South Alabama | W | 79-83 |
| NCAAB | 2022/03/17 00:00 | SE Louisiana v South Alabama | W | 68-70 |
| NCAAB | 2022/03/03 20:00 | Arkansas LR v South Alabama | L | 75-71 |
| NCAAB | 2022/02/26 20:00 | UT Arlington v South Alabama | W | 52-62 |
| NCAAB | 2022/02/24 01:00 | Texas State v South Alabama | L | 55-52 |
| NCAAB | 2022/02/19 21:30 | South Alabama v Appalachian State | L | 51-69 |
| NCAAB | 2022/02/18 00:00 | South Alabama v Coastal Carolina | W | 71-68 |
| NIT | 2022/03/16 23:00 | Towson v Wake Forest | L | 64-74 |
| NCAAB | 2022/03/07 23:00 | Delaware v Towson | L | 69-56 |
| NCAAB | 2022/03/06 17:00 | Northeastern v Towson | W | 61-68 |
| NCAAB | 2022/02/26 21:00 | Towson v James Madison | W | 95-59 |
| NCAAB | 2022/02/24 00:00 | James Madison v Towson | W | 65-84 |
| NCAAB | 2022/02/19 21:00 | Towson v Coll of Charleston | W | 80-77 |
| NCAAB | 2022/02/17 23:00 | Towson v UNC Wilmington | W | 79-55 |
| NCAAB | 2022/02/12 19:00 | Elon v Towson | W | 50-86 |