Stadium: Smith-Hammond-Middleton Memorial Center
Home Manager: Bucky McMillan Away Manager: Erik Martin
| NCAAB | 2022/03/06 23:30 | Samford v Furman | L | 68-71 |
| NCAAB | 2022/03/06 01:30 | NC Greensboro v Samford | W | 64-66 |
| NCAAB | 2022/02/26 21:00 | Samford v Chattanooga | L | 57-70 |
| NCAAB | 2022/02/24 01:00 | Furman v Samford | W | 75-83 |
| NCAAB | 2022/02/22 01:00 | The Citadel v Samford | W | 74-76 |
| NCAAB | 2022/02/19 20:00 | NC Greensboro v Samford | W | 49-55 |
| NCAAB | 2022/02/18 01:00 | VMI v Samford | W | 99-100 |
| NCAAB | 2022/02/12 21:00 | Samford v East Tenn St | W | 77-73 |
| NCAAB | 2022/03/10 23:00 | South Carolina State v Morgan State | L | 77-80 |
| NCAAB | 2022/03/04 00:30 | South Carolina State v North Carolina Central | L | 62-67 |
| NCAAB | 2022/03/01 00:30 | South Carolina State v Howard | L | 62-72 |
| NCAAB | 2022/02/26 23:00 | South Carolina State v Norfolk State | L | 59-63 |
| NCAAB | 2022/02/22 00:30 | Delaware State v South Carolina State | W | 74-79 |
| NCAAB | 2022/02/19 21:00 | Maryland Eastern-Shore v South Carolina State | W | 63-70 |
| NCAAB | 2022/02/15 00:30 | South Carolina State v Morgan State | L | 66-76 |
| NCAAB | 2022/02/12 21:00 | South Carolina State v Coppin State | W | 66-58 |