Stadium: Carver-Hawkeye Arena
Home Manager: Tom Izzo Away Manager: Fran McCaffery
| NCAAB | 2022/02/23 00:00 | Michigan State v Iowa | L | 60-86 |
| NCAAB | 2021/02/13 19:30 | Iowa v Michigan State | L | 88-58 |
| NCAAB | 2021/02/03 00:00 | Michigan State v Iowa | L | 78-84 |
| NCAAB | 2020/02/26 00:00 | Iowa v Michigan State | W | 70-78 |
| NCAAB | 2019/01/25 00:00 | Michigan State v Iowa | W | 82-67 |
| NCAAB | 2018/12/03 23:30 | Iowa v Michigan State | W | 68-90 |
| NCAAB | 2018/02/07 02:00 | Michigan State v Iowa | W | 96-93 |
| NCAAB | 2017/02/11 23:00 | Iowa v Michigan State | W | 66-77 |
| NCAAB | 2022/03/20 21:15 | Michigan State v Duke | L | 76-85 |
| NCAAB | 2022/03/19 01:40 | Davidson v Michigan State | W | 73-74 |
| NCAAB | 2022/03/12 20:30 | Michigan State v Purdue | L | 70-75 |
| NCAAB | 2022/03/11 23:30 | Michigan State v Wisconsin | W | 69-63 |
| NCAAB | 2022/03/10 23:30 | Maryland v Michigan State | W | 72-76 |
| NCAAB | 2022/03/06 21:30 | Maryland v Michigan State | W | 67-77 |
| NCAAB | 2022/03/04 00:00 | Michigan State v Ohio State | L | 69-80 |
| NCAAB | 2022/03/02 01:30 | Michigan State v Michigan | L | 70-87 |
| NCAAB | 2022/03/17 19:10 | Richmond v Iowa | L | 67-63 |
| NCAAB | 2022/03/13 19:30 | Iowa v Purdue | W | 75-66 |
| NCAAB | 2022/03/12 18:00 | Indiana v Iowa | W | 77-80 |
| NCAAB | 2022/03/11 19:00 | Iowa v Rutgers | W | 84-74 |
| NCAAB | 2022/03/10 19:00 | Northwestern v Iowa | W | 76-112 |
| NCAAB | 2022/03/07 00:30 | Iowa v Illinois | L | 72-74 |
| NCAAB | 2022/03/04 02:00 | Iowa v Michigan | W | 82-71 |
| NCAAB | 2022/03/01 01:00 | Northwestern v Iowa | W | 61-82 |