Stadium: Carnesecca Arena
Home Manager: Mike Jordan Away Manager: Mike Anderson
| NCAAB | 2022/03/02 00:00 | Bucknell v Lafayette | L | 82-81 |
| NCAAB | 2022/02/26 19:00 | Lehigh v Lafayette | L | 78-58 |
| NCAAB | 2022/02/24 00:00 | Lafayette v Boston U | L | 60-76 |
| NCAAB | 2022/02/22 00:00 | Holy Cross v Lafayette | W | 61-84 |
| NCAAB | 2022/02/19 21:00 | Lafayette v Bucknell | L | 89-92 |
| NCAAB | 2022/02/17 00:00 | Loyola Maryland v Lafayette | W | 68-77 |
| NCAAB | 2022/02/14 23:00 | Lafayette v Colgate | L | 61-69 |
| NCAAB | 2022/02/12 17:00 | Lafayette v Lehigh | W | 73-69 |
| NCAAB | 2022/03/11 00:00 | St Johns v Villanova | L | 65-66 |
| NCAAB | 2022/03/10 00:00 | DePaul v St Johns | W | 73-92 |
| NCAAB | 2022/03/06 02:00 | St Johns v Marquette | L | 77-85 |
| NCAAB | 2022/03/02 23:30 | Xavier v St Johns | W | 66-81 |
| NCAAB | 2022/02/27 22:00 | St Johns v DePaul | L | 94-99 |
| NCAAB | 2022/02/23 23:30 | Creighton v St Johns | L | 81-78 |
| NCAAB | 2022/02/18 22:00 | Butler v St Johns | W | 57-91 |
| NCAAB | 2022/02/16 23:30 | St Johns v Xavier | W | 86-73 |