Stadium: The Buc Dome
Home Manager: Barclay Radebaugh Away Manager: Dave Dickerson
| NCAAB | 2022/03/04 19:30 | Charleston Southern v USC Upstate | W | 62-72 |
| NCAAB | 2022/02/19 22:30 | USC Upstate v Charleston Southern | W | 78-73 |
| NCAAB | 2022/01/22 21:00 | Charleston Southern v USC Upstate | W | 57-70 |
| NCAAB | 2020/02/10 23:00 | Charleston Southern v USC Upstate | W | 52-66 |
| NCAAB | 2020/01/03 00:30 | USC Upstate v Charleston Southern | L | 75-89 |
| NCAAB | 2019/03/06 00:00 | USC Upstate v Charleston Southern | L | 52-71 |
| NCAAB | 2019/02/22 00:30 | USC Upstate v Charleston Southern | L | 60-92 |
| NCAAB | 2019/02/02 21:30 | Charleston Southern v USC Upstate | L | 90-71 |
| NCAAB | 2022/03/22 00:00 | USC Upstate v South Alabama | L | 79-83 |
| NCAAB | 2022/03/15 22:30 | USC Upstate v Appalachian State | W | 80-74 |
| NCAAB | 2022/03/05 17:00 | USC Upstate v Longwood | L | 70-79 |
| NCAAB | 2022/03/04 19:30 | Charleston Southern v USC Upstate | W | 62-72 |
| NCAAB | 2022/02/26 21:00 | Gardner Webb v USC Upstate | W | 70-72 |
| NCAAB | 2022/02/25 00:00 | USC Upstate v Winthrop | L | 59-89 |
| NCAAB | 2022/02/19 22:30 | USC Upstate v Charleston Southern | W | 78-73 |
| NCAAB | 2022/02/16 23:00 | Presbyterian v USC Upstate | W | 55-60 |
| NCAAB | 2022/03/04 19:30 | Charleston Southern v USC Upstate | L | 62-72 |
| NCAAB | 2022/03/02 19:00 | Charleston Southern v UNC Asheville | W | 79-78 |
| NCAAB | 2022/02/26 21:00 | Charleston Southern v Winthrop | L | 86-92 |
| NCAAB | 2022/02/24 00:00 | Charleston Southern v Presbyterian | L | 48-68 |
| NCAAB | 2022/02/19 22:30 | USC Upstate v Charleston Southern | L | 78-73 |
| NCAAB | 2022/02/17 00:00 | UNC Asheville v Charleston Southern | L | 85-66 |
| NCAAB | 2022/02/12 19:00 | Charleston Southern v Gardner Webb | L | 65-82 |
| NCAAB | 2022/02/10 00:00 | Charleston Southern v North Carolina A&T | L | 51-62 |