Stadium: Knapp Center
Home Manager: Bryan Mullins Away Manager: Darian DeVries
| NCAAB | 2022/03/05 02:30 | Southern Illinois v Drake | L | 52-65 |
| NCAAB | 2022/02/26 21:00 | Southern Illinois v Drake | L | 60-62 |
| NCAAB | 2022/01/18 01:00 | Drake v Southern Illinois | L | 60-59 |
| NCAAB | 2021/01/05 00:00 | Southern Illinois v Drake | L | 55-86 |
| NCAAB | 2021/01/03 23:00 | Southern Illinois v Drake | L | 55-73 |
| NCAAB | 2020/02/01 23:00 | Southern Illinois v Drake | W | 79-72 |
| NCAAB | 2020/01/19 21:00 | Drake v Southern Illinois | W | 49-66 |
| NCAAB | 2019/02/13 01:00 | Drake v Southern Illinois | L | 72-69 |
| NCAAB | 2022/12/01 01:00 | Southern Illinois v Evansville | W | 80-53 |
| NCAAB | 2022/11/24 06:00 | California Baptist v Southern Illinois | W | 61-64 |
| NCAAB | 2022/11/22 06:00 | Southern Illinois v UNLV | L | 49-56 |
| NCAAB | 2022/11/18 01:00 | Tennessee State v Southern Illinois | W | 44-57 |
| NCAAB | 2022/11/13 21:00 | Southern Illinois v Southern Indiana | L | 53-71 |
| NCAAB | 2022/11/11 01:00 | Southern Illinois v Oklahoma State | W | 61-60 |
| NCAAB | 2022/11/08 01:00 | Arkansas LR v Southern Illinois | W | 63-94 |
| NCAAB | 2022/03/05 02:30 | Southern Illinois v Drake | L | 52-65 |
| NCAAB | 2022/12/01 00:00 | Drake v Indiana State | L | 73-75 |
| NCAAB | 2022/11/26 23:00 | UL Lafayette v Drake | W | 64-76 |
| NCAAB | 2022/11/22 01:00 | Drake v Tarleton State | W | 71-64 |
| NCAAB | 2022/11/20 22:45 | Drake v Wyoming | W | 61-56 |
| NCAAB | 2022/11/18 18:00 | Buffalo v Drake | W | 72-80 |
| NCAAB | 2022/11/15 01:00 | Wofford v Drake | W | 72-80 |
| NCAAB | 2022/11/10 01:00 | IU Indianapolis v Drake | W | 48-80 |
| CBI | 2022/03/21 17:00 | Drake v UNC Wilmington | L | 75-76 |