Stadium: Jenny Craig Pavilion
Home Manager: Steve Lavin Away Manager: Herb Sendek
| NCAAB | 2022/02/06 00:00 | Santa Clara v San Diego | W | 79-66 |
| NCAAB | 2022/01/25 02:00 | San Diego v Santa Clara | W | 74-78 |
| NCAAB | 2021/02/19 02:00 | San Diego v Santa Clara | L | 71-60 |
| NCAAB | 2021/01/17 22:00 | Santa Clara v San Diego | W | 69-63 |
| NCAAB | 2020/01/25 23:00 | Santa Clara v San Diego | W | 65-52 |
| NCAAB | 2020/01/04 22:00 | San Diego v Santa Clara | W | 63-80 |
| NCAAB | 2019/03/09 04:20 | San Diego v Santa Clara | L | 62-45 |
| NCAAB | 2019/01/04 03:00 | San Diego v Santa Clara | W | 56-68 |
| NIT | 2022/03/16 03:00 | Santa Clara v Washington State | L | 50-63 |
| NCAAB | 2022/03/08 04:30 | Santa Clara v Saint Mary's CA | L | 72-75 |
| NCAAB | 2022/03/06 05:30 | Portland v Santa Clara | W | 67-91 |
| NCAAB | 2022/02/26 22:00 | Portland v Santa Clara | W | 89-102 |
| NCAAB | 2022/02/25 03:00 | Santa Clara v Pepperdine | W | 89-73 |
| NCAAB | 2022/02/20 02:00 | Santa Clara v Gonzaga | L | 69-81 |
| NCAAB | 2022/02/17 08:27 | Santa Clara v Loyola Marymount | W | 84-80 |
| NCAAB | 2022/02/12 23:00 | San Francisco v Santa Clara | L | 74-58 |
| NCAAB | 2022/03/05 04:00 | San Diego v Portland | L | 55-73 |
| NCAAB | 2022/03/04 04:00 | Pepperdine v San Diego | W | 67-74 |
| NCAAB | 2022/02/26 22:00 | San Francisco v San Diego | L | 78-62 |
| NCAAB | 2022/02/25 03:00 | Saint Mary's CA v San Diego | L | 60-46 |
| NCAAB | 2022/02/17 08:27 | San Diego v Portland | L | 60-92 |
| NCAAB | 2022/02/13 02:00 | Pacific v San Diego | W | 54-60 |
| NCAAB | 2022/02/11 02:00 | San Diego v Saint Mary's CA | L | 57-86 |
| NCAAB | 2022/02/06 00:00 | Santa Clara v San Diego | L | 79-66 |