| England FA Premier Women | 2022/01/23 14:00 | Sheffield FC (W) v Loughborough Lightning (W) | D | 1-1 |
| England FA Premier Women | 2022/09/04 13:00 | Wolverhampton (W) v Loughborough Lightning (W) | L | 4-0 |
| England FA Premier Women | 2022/08/31 18:45 | Derby (W) v Loughborough Lightning (W) | L | 5-0 |
| England FA Premier Women | 2022/08/28 13:00 | West Brom (W) v Loughborough Lightning (W) | L | 4-1 |
| England FA Premier Women | 2022/08/21 15:00 | Loughborough Lightning (W) v Stoke (W) | L | 0-3 |
| England FA Premier Women | 2022/05/01 13:00 | Wolverhampton (W) v Loughborough Lightning (W) | L | 4-0 |
| England FA Premier Women | 2022/04/24 13:00 | Loughborough Lightning (W) v AFC Fylde Women | W | 4-1 |
| England FA Premier Women | 2022/04/17 13:00 | Huddersfield (W) v Loughborough Lightning (W) | D | 2-2 |
| England FA Premier Women | 2022/04/13 18:45 | Loughborough Lightning (W) v Nottm Forest (W) | D | 1-1 |
| England FA Premier Women | 2022/05/01 13:00 | Sheffield FC (W) v Derby (W) | L | 0-2 |
| England FA Premier Women | 2022/04/28 18:45 | Sheffield FC (W) v Brighouse Town Women | L | 0-3 |
| England FA Premier Women | 2022/04/24 13:00 | Sheffield FC (W) v Middlesbrough (W) | D | 1-1 |
| England FA Premier Women | 2022/04/21 18:45 | Brighouse Town Women v Sheffield FC (W) | L | 1-0 |
| England FA Premier Women | 2022/04/17 13:00 | Sheffield FC (W) v AFC Fylde Women | L | 0-2 |
| England FA Premier Women | 2022/04/03 13:00 | Sheffield FC (W) v West Brom (W) | L | 0-2 |
| England FA Premier Women | 2022/03/27 13:00 | Sheffield FC (W) v Wolverhampton (W) | L | 0-5 |
| England FA Premier Women | 2022/03/20 14:00 | Hull (W) v Sheffield FC (W) | L | 4-0 |