Stadium: Liberty Arena
Home Manager: Samantha Quigley Smith Away Manager: Frederick Jones Goldstein
| WNCAAB | 2022/03/03 21:30 | Murray State (W) v SIU Edwardsville (W) | L | 84-76 |
| WNCAAB | 2022/03/02 21:30 | Tennessee Martin (W) v SIU Edwardsville (W) | W | 84-86 |
| WNCAAB | 2022/02/26 19:00 | Morehead State (W) v SIU Edwardsville (W) | W | 77-94 |
| WNCAAB | 2022/02/24 23:30 | Austin Peay (W) v SIU Edwardsville (W) | W | 61-71 |
| WNCAAB | 2022/02/19 20:00 | SIU Edwardsville (W) v Belmont (W) | L | 50-88 |
| WNCAAB | 2022/02/17 23:30 | SIU Edwardsville (W) v Tennessee State (W) | W | 86-76 |
| WNCAAB | 2022/02/12 18:00 | Tennessee Tech (W) v SIU Edwardsville (W) | L | 68-64 |
| WNCAAB | 2022/02/10 17:00 | Tennessee Martin (W) v SIU Edwardsville (W) | L | 67-62 |
| WNCAAB Extra Games | 2022/03/12 00:30 | Southern Indiana (W) v Walsh (W) | L | 63-75 |