Stadium: Clemens Stadium Round: 7
| NCAAF | 2021/11/27 18:00 | St Johns Johnnies v Linfield Wildcats | L | 28-31 |
| NCAAF | 2021/11/20 18:00 | St Johns Johnnies v Lake Forest Foresters | W | 41-14 |
| NCAAF | 2021/11/06 18:00 | Carleton Knights v St Johns Johnnies | W | 10-38 |
| NCAAF | 2021/10/30 18:00 | St Johns Johnnies v St Scholastica Saints | W | 81-0 |
| NCAAF | 2021/10/23 18:00 | Gustavus Adolphus Gusties v St Johns Johnnies | W | 7-37 |
| NCAAF | 2021/10/16 18:00 | St Johns Johnnies v St Olaf Oles | W | 56-0 |
| NCAAF | 2021/10/09 18:00 | St Johns Johnnies v Augsburg Auggies | W | 50-0 |
| NCAAF | 2021/10/02 18:00 | Concordia-Moorhead Cobbers v St Johns Johnnies | W | 0-49 |
| NCAAF | 2021/11/18 00:00 | Northwestern Eagles v Crown Storm | W | 59-20 |
| NCAAF | 2021/11/13 19:00 | Martin Luther Knights v Northwestern Eagles | L | 27-21 |
| NCAAF | 2021/10/30 23:00 | Minnesota Morris Cougars v Northwestern Eagles | L | 28-21 |
| NCAAF | 2021/10/23 17:00 | Northwestern Eagles v Westminster Blue Jays | W | 45-28 |
| NCAAF | 2021/10/09 17:00 | Greenville Panthers v Northwestern Eagles | L | 35-23 |
| NCAAF | 2021/10/02 17:00 | Northwestern Eagles v Finlandia Lions | W | 16-13 |
| NCAAF | 2021/09/25 17:00 | Hope Flying Dutchmen v Northwestern Eagles | L | 52-10 |
| NCAAF | 2021/09/18 23:00 | Northwestern Eagles v Uw-River Falls Falcons | L | 13-71 |