Home History
| England Development League 2 | 2022/10/18 18:00 | Colchester U21 v Reading U21 | D | 2-2 |
| England U21 Premier League Cup | 2022/10/14 18:00 | Colchester U21 v Birmingham U21 | W | 2-1 |
| England Development League 2 | 2022/10/11 12:00 | Colchester U21 v Bristol City U21 | L | 0-1 |
| England Development League 2 | 2022/10/03 14:00 | Swansea U21 v Colchester U21 | L | 4-1 |
| England Development League 2 | 2022/09/23 12:00 | QPR U21 v Colchester U21 | L | 2-0 |
| England Development League 2 | 2022/09/16 13:30 | Colchester U21 v Ipswich U21 | W | 2-1 |
| England Development League 2 | 2022/09/12 13:00 | Charlton U21 v Colchester U21 | D | 2-2 |
| England Development League 2 | 2022/09/05 18:00 | Birmingham U21 v Colchester U21 | L | 5-0 |
Away History
| England EFL Trophy | 2022/10/18 18:00 | Hartlepool v Everton U21 | W | 0-6 |
| England Premier League 2 | 2022/10/09 13:00 | Crystal Palace U21 v Everton U21 | W | 3-4 |
| England EFL Trophy | 2022/10/04 18:00 | Harrogate Town v Everton U21 | D | 1-1 |
| England Premier League 2 | 2022/09/30 18:00 | Fulham U21 v Everton U21 | L | 2-0 |
| England Premier League 2 | 2022/09/18 11:00 | Everton U21 v Brighton U21 | W | 1-0 |
| England Premier League 2 | 2022/09/03 11:00 | Everton U21 v Chelsea U21 | L | 0-2 |
| England EFL Trophy | 2022/08/30 18:00 | Morecambe v Everton U21 | D | 3-3 |
| England Premier League 2 | 2022/08/27 11:00 | West Ham U21 v Everton U21 | W | 1-2 |