[20] BUF Sabres 1-2 FLA Panthers [18] 2022-11-20 23:00
Stadium: Amerant Bank Arena
Home Manager: Don Granato Away Manager: Paul Maurice
Head to Head
| NHL | 2022/10/15 17:00 | FLA Panthers v BUF Sabres | L | 4-3 |
| NHL | 2022/04/08 23:00 | BUF Sabres v FLA Panthers | L | 3-4 |
| NHL | 2022/04/03 17:00 | FLA Panthers v BUF Sabres | L | 5-3 |
| NHL | 2022/03/08 00:00 | FLA Panthers v BUF Sabres | L | 6-1 |
| NHL | 2021/12/03 00:00 | BUF Sabres v FLA Panthers | L | 4-7 |
| NHL | 2020/01/04 18:00 | FLA Panthers v BUF Sabres | W | 2-3 |
| NHL | 2019/11/24 22:00 | BUF Sabres v FLA Panthers | W | 5-2 |
| NHL | 2019/10/11 23:00 | FLA Panthers v BUF Sabres | W | 2-3 |
Home History
| NHL | 2022/11/20 00:00 | BUF Sabres v TOR Maple Leafs | L | 2-5 |
| NHL | 2022/11/17 00:00 | BUF Sabres v OTT Senators | L | 1-4 |
| NHL | 2022/11/16 00:00 | VAN Canucks v BUF Sabres | L | 5-4 |
| NHL | 2022/11/13 00:00 | BOS Bruins v BUF Sabres | L | 3-1 |
| NHL | 2022/11/11 00:00 | VGS Golden Knights v BUF Sabres | L | 7-4 |
| NHL | 2022/11/09 00:00 | ARZ Coyotes v BUF Sabres | L | 4-1 |
| NHL | 2022/11/05 23:00 | BUF Sabres v TB Lightning | L | 3-5 |
| NHL | 2022/11/04 23:00 | BUF Sabres v CAR Hurricanes | L | 3-5 |
Away History
| NHL | 2022/11/19 21:00 | CGY Flames v FLA Panthers | L | 5-4 |
| NHL | 2022/11/18 00:00 | DAL Stars v FLA Panthers | L | 6-4 |
| NHL | 2022/11/16 00:00 | WAS Capitals v FLA Panthers | W | 2-5 |
| NHL | 2022/11/12 21:00 | EDM Oilers v FLA Panthers | L | 4-2 |
| NHL | 2022/11/10 00:00 | CAR Hurricanes v FLA Panthers | W | 0-3 |
| NHL | 2022/11/07 02:00 | FLA Panthers v ANA Ducks | W | 5-3 |
| NHL | 2022/11/06 02:30 | FLA Panthers v LA Kings | L | 4-5 |
| NHL | 2022/11/04 02:30 | FLA Panthers v SJ Sharks | W | 4-3 |