Stadium: Frank "Muddy" Waters Stadium Round: 1
| NCAAF | 2022/09/03 19:00 | Lake Erie v Hillsdale Chargers | W | 31-35 |
| NCAAF | 2021/10/16 17:00 | Hillsdale Chargers v Lake Erie | L | 14-33 |
| NCAAF | 2019/09/21 20:00 | Hillsdale Chargers v Lake Erie | W | 34-14 |
| NCAAF | 2018/09/22 20:00 | Hillsdale Chargers v Lake Erie | W | 41-7 |
| NCAAF | 2022/11/12 18:00 | Ohio Dominican Panthers v Hillsdale Chargers | L | 20-10 |
| NCAAF | 2022/11/05 17:00 | Hillsdale Chargers v Michigan Technological University Huskies | L | 24-28 |
| NCAAF | 2022/10/29 17:00 | Hillsdale Chargers v Ashland Eagles | W | 36-20 |
| NCAAF | 2022/10/22 18:00 | Hillsdale Chargers v Findlay Oilers | L | 20-41 |
| NCAAF | 2022/10/15 17:00 | Northwood Timberwolves v Hillsdale Chargers | W | 7-41 |
| NCAAF | 2022/10/08 20:00 | Hillsdale Chargers v Tiffin Dragons | L | 0-41 |
| NCAAF | 2022/10/01 23:00 | Kentucky Wesleyan v Hillsdale Chargers | L | 31-27 |
| NCAAF | 2022/09/24 23:00 | Missouri S&t Miners v Hillsdale Chargers | W | 10-17 |
| NCAAF | 2022/11/12 17:00 | Lake Erie v Northern Michigan Wildcats | L | 11-33 |
| NCAAF | 2022/11/05 20:00 | Lake Erie v Ashland Eagles | L | 23-31 |
| NCAAF | 2022/10/29 16:00 | Findlay Oilers v Lake Erie | L | 42-17 |
| NCAAF | 2022/10/22 18:00 | Lake Erie v Northwood Timberwolves | W | 21-18 |
| NCAAF | 2022/10/15 16:00 | Walsh U. Cavaliers v Lake Erie | W | 15-22 |
| NCAAF | 2022/10/08 16:00 | Lake Erie v Ohio Dominican Panthers | L | 7-38 |
| NCAAF | 2022/10/01 20:00 | Tiffin Dragons v Lake Erie | L | 52-27 |
| NCAAF | 2022/09/24 18:00 | Southwest Baptist University Bearcats v Lake Erie | L | 52-31 |