Stadium: Drake Stadium Round: 1
Home Manager: Todd Stepsis Away Manager: Glenn Caruso
| NCAAF | 2022/10/15 18:00 | Drake Bulldogs v St. Thomas (MN) | W | 14-26 |
| NCAAF | 2021/11/13 18:00 | St. Thomas (MN) v Drake Bulldogs | W | 21-14 |
| NCAAF | 2022/11/19 17:00 | St. Thomas (MN) v Butler | W | 27-13 |
| NCAAF | 2022/11/12 18:00 | Stetson Hatters v St. Thomas (MN) | W | 0-23 |
| NCAAF | 2022/11/05 18:00 | St. Thomas (MN) v Valparaiso | W | 34-7 |
| NCAAF | 2022/10/29 17:00 | San Diego v St. Thomas (MN) | W | 42-49 |
| NCAAF | 2022/10/22 17:00 | St. Thomas (MN) v Presbyterian | W | 46-17 |
| NCAAF | 2022/10/15 18:00 | Drake Bulldogs v St. Thomas (MN) | W | 14-26 |
| NCAAF | 2022/10/08 18:00 | Davidson Wildcats v St. Thomas (MN) | W | 16-27 |
| NCAAF | 2022/10/01 16:00 | St. Thomas (MN) v Marist | W | 38-24 |
| NCAAF | 2022/11/19 18:00 | Drake Bulldogs v Valparaiso | W | 24-0 |
| NCAAF | 2022/11/12 19:00 | Butler v Drake Bulldogs | W | 24-27 |
| NCAAF | 2022/10/29 17:00 | Drake Bulldogs v Stetson Hatters | W | 24-17 |
| NCAAF | 2022/10/22 18:00 | Davidson Wildcats v Drake Bulldogs | L | 48-14 |
| NCAAF | 2022/10/15 18:00 | Drake Bulldogs v St. Thomas (MN) | L | 14-26 |
| NCAAF | 2022/10/08 18:00 | San Diego v Drake Bulldogs | L | 22-10 |
| NCAAF | 2022/10/01 17:00 | Drake Bulldogs v Dayton | L | 14-27 |
| NCAAF | 2022/09/24 18:00 | Marist v Drake Bulldogs | L | 30-25 |