Stadium: Ray and Sue Smith Stadium Round: 1
| NCAAF | 2022/11/05 17:00 | Trine Thunder v Hope Flying Dutchmen | W | 21-28 |
| NCAAF | 2022/10/29 17:00 | Hope Flying Dutchmen v Kalamazoo Hornets | W | 66-20 |
| NCAAF | 2022/10/22 18:00 | Hope Flying Dutchmen v Olivet Comets | W | 23-0 |
| NCAAF | 2022/10/15 17:00 | Alma College Scots v Hope Flying Dutchmen | L | 28-26 |
| NCAAF | 2022/10/08 16:00 | Albion Britons v Hope Flying Dutchmen | L | 30-10 |
| NCAAF | 2022/10/01 19:00 | Hope Flying Dutchmen v Adrian Bulldogs | L | 10-22 |
| NCAAF | 2022/09/24 17:00 | Northwestern Eagles v Hope Flying Dutchmen | W | 7-56 |
| NCAAF | 2022/09/17 17:30 | Mount St. Joseph Lions v Hope Flying Dutchmen | L | 33-28 |
| NCAAF | 2022/11/19 17:00 | Alma College Scots v Mount St. Joseph Lions | L | 41-21 |
| NCAAF | 2022/11/12 18:30 | Mount St. Joseph Lions v Rose Hulman Engineers | W | 40-31 |
| NCAAF | 2022/11/05 17:30 | Franklin College Grizzlies v Mount St. Joseph Lions | W | 20-27 |
| NCAAF | 2022/10/29 17:30 | Mount St. Joseph Lions v Bluffton Beavers | W | 70-21 |
| NCAAF | 2022/10/22 17:30 | Hanover v Mount St. Joseph Lions | W | 29-44 |
| NCAAF | 2022/10/15 17:30 | Anderson Ravens v Mount St. Joseph Lions | W | 3-59 |
| NCAAF | 2022/10/08 17:30 | Mount St. Joseph Lions v Defiance Yellow Jackets | W | 55-35 |
| NCAAF | 2022/10/01 17:30 | Manchester Spartans v Mount St. Joseph Lions | W | 20-55 |