Stadium: BB&T Field Round: 1
| NCAAF | 2022/11/19 17:00 | Susquehanna Crusaders v Utica Pioneers | L | 10-17 |
| NCAAF | 2022/11/12 18:00 | Susquehanna Crusaders v Juniata Eagles | W | 66-15 |
| NCAAF | 2022/11/05 17:00 | Muhlenberg Mules v Susquehanna Crusaders | W | 24-28 |
| NCAAF | 2022/10/29 17:00 | Susquehanna Crusaders v Johns Hopkins Blue Jays | W | 26-24 |
| NCAAF | 2022/10/22 17:00 | Mcdaniel Green Terror v Susquehanna Crusaders | W | 0-58 |
| NCAAF | 2022/10/15 16:00 | Gettysburg Bullets v Susquehanna Crusaders | W | 7-41 |
| NCAAF | 2022/10/01 17:30 | Susquehanna Crusaders v Ursinus Bears | W | 17-12 |
| NCAAF | 2022/09/24 17:00 | Dickinson Red Devils v Susquehanna Crusaders | W | 0-45 |
| NCAAF | 2022/11/12 17:00 | Catholic Cardinals v Springfield Pride | L | 21-35 |
| NCAAF | 2022/11/05 16:00 | Norwich Cadets v Catholic Cardinals | W | 14-31 |
| NCAAF | 2022/10/22 17:00 | Catholic Cardinals v Merchant Marine Mariners | W | 41-33 |
| NCAAF | 2022/10/15 17:30 | Coast Guard Bears v Catholic Cardinals | W | 17-24 |
| NCAAF | 2022/10/08 17:00 | Catholic Cardinals v Wpi Engineers | W | 24-21 |
| NCAAF | 2022/10/01 17:00 | Mit Engineers v Catholic Cardinals | W | 7-42 |
| NCAAF | 2022/09/24 18:00 | Christopher Newport Captains v Catholic Cardinals | L | 38-7 |
| NCAAF | 2022/09/17 17:00 | Catholic Cardinals v Kean Cougars | L | 14-33 |