Stadium: Schmidt Stadium Round: 1
| NCAAF | 2022/11/12 17:00 | Wilkes Colonels v Kings Monarchs | W | 58-42 |
| NCAAF | 2022/11/05 16:00 | Stevenson Mustangs v Wilkes Colonels | L | 28-0 |
| NCAAF | 2022/10/29 16:00 | Wilkes Colonels v Lycoming Warriors | W | 24-7 |
| NCAAF | 2022/10/22 17:00 | Delaware Valley Aggies v Wilkes Colonels | L | 27-14 |
| NCAAF | 2022/10/15 16:00 | Wilkes Colonels v Misericordia Cougars | W | 28-0 |
| NCAAF | 2022/10/08 16:00 | Alvernia Golden Wolves v Wilkes Colonels | W | 14-35 |
| NCAAF | 2022/10/01 16:00 | Wilkes Colonels v Albright Lions | W | 27-0 |
| NCAAF | 2022/09/24 17:00 | Lebanon Valley Flying Dutchmen v Wilkes Colonels | L | 24-19 |
| NCAAF | 2022/11/12 18:00 | Susquehanna Crusaders v Juniata Eagles | L | 66-15 |
| NCAAF | 2022/11/05 16:00 | Juniata Eagles v Ursinus Bears | L | 2-65 |
| NCAAF | 2022/10/29 17:00 | Dickinson Red Devils v Juniata Eagles | L | 45-7 |
| NCAAF | 2022/10/22 16:00 | Juniata Eagles v Muhlenberg Mules | L | 12-57 |
| NCAAF | 2022/10/15 17:00 | Juniata Eagles v Franklin And Marshall Diplomats | L | 13-38 |
| NCAAF | 2022/10/01 16:00 | Moravian Greyhounds v Juniata Eagles | L | 51-7 |
| NCAAF | 2022/09/24 17:00 | Juniata Eagles v Gettysburg Bullets | L | 14-40 |
| NCAAF | 2022/09/17 17:00 | Johns Hopkins Blue Jays v Juniata Eagles | L | 70-0 |