Stadium: Leckonby Stadium Round: 1
| NCAAF | 2022/10/29 16:00 | Rochester Yellowjackets v St Lawrence Saints | W | 31-35 |
| NCAAF | 2021/10/30 17:00 | St Lawrence Saints v Rochester Yellowjackets | W | 34-10 |
| NCAAF | 2019/11/09 18:00 | St Lawrence Saints v Rochester Yellowjackets | W | 51-19 |
| NCAAF | 2018/10/06 17:00 | Rochester Yellowjackets v St Lawrence Saints | W | 24-38 |
| NCAAF | 2022/11/12 18:00 | St Lawrence Saints v Buffalo State Bengals | W | 31-7 |
| NCAAF | 2022/11/05 16:00 | Rpi Engineers v St Lawrence Saints | L | 10-6 |
| NCAAF | 2022/10/29 16:00 | Rochester Yellowjackets v St Lawrence Saints | W | 31-35 |
| NCAAF | 2022/10/22 17:00 | St Lawrence Saints v Hobart Statesmen | L | 10-31 |
| NCAAF | 2022/10/15 17:00 | Ithaca Bombers v St Lawrence Saints | L | 40-0 |
| NCAAF | 2022/10/08 17:00 | St Lawrence Saints v Union Dutchmen | L | 7-44 |
| NCAAF | 2022/09/24 16:00 | Castleton Spartans v St Lawrence Saints | W | 6-34 |
| NCAAF | 2022/09/16 23:00 | St Lawrence Saints v Morrisville State Mustangs | L | 15-17 |
| NCAAF | 2022/11/12 18:00 | Hobart Statesmen v Rochester Yellowjackets | L | 27-7 |
| NCAAF | 2022/11/05 16:00 | Rochester Yellowjackets v Hartwick Hawks | W | 19-13 |
| NCAAF | 2022/10/29 16:00 | Rochester Yellowjackets v St Lawrence Saints | L | 31-35 |
| NCAAF | 2022/10/22 16:00 | Union Dutchmen v Rochester Yellowjackets | L | 27-7 |
| NCAAF | 2022/10/15 16:00 | Rochester Yellowjackets v Buffalo State Bengals | W | 12-6 |
| NCAAF | 2022/10/08 17:00 | Ithaca Bombers v Rochester Yellowjackets | L | 56-10 |
| NCAAF | 2022/10/01 17:00 | Rochester Yellowjackets v Rpi Engineers | L | 3-31 |
| NCAAF | 2022/09/17 16:00 | Rochester Yellowjackets v Brockport Golden Eagles | L | 3-23 |