Stadium: Armfield Athletic Center Round: 1
| NCAAF | 2022/10/15 17:00 | Shenandoah Hornets v Guilford Quakers | L | 38-35 |
| NCAAF | 2021/10/09 16:00 | Guilford Quakers v Shenandoah Hornets | L | 25-52 |
| NCAAF | 2019/09/28 17:00 | Guilford Quakers v Shenandoah Hornets | L | 7-26 |
| NCAAF | 2018/11/03 17:00 | Shenandoah Hornets v Guilford Quakers | L | 62-47 |
| NCAAF | 2022/11/12 18:00 | Guilford Quakers v Bridgewater Eagles | L | 22-64 |
| NCAAF | 2022/11/05 17:00 | Averett Cougars v Guilford Quakers | W | 0-26 |
| NCAAF | 2022/10/29 17:00 | Hampden Sydney Tigers v Guilford Quakers | L | 28-21 |
| NCAAF | 2022/10/22 17:00 | Guilford Quakers v Ferrum Panthers | L | 17-31 |
| NCAAF | 2022/10/15 17:00 | Shenandoah Hornets v Guilford Quakers | L | 38-35 |
| NCAAF | 2022/10/08 18:00 | Guilford Quakers v Washington And Lee Generals | L | 6-31 |
| NCAAF | 2022/10/01 17:00 | Randolph Macon Yellow Jackets v Guilford Quakers | L | 48-19 |
| NCAAF | 2022/09/17 17:00 | Guilford Quakers v Huntingdon Hawks | L | 7-47 |
| NCAAF | 2022/11/12 18:00 | Washington And Lee Generals v Shenandoah Hornets | W | 14-16 |
| NCAAF | 2022/11/05 17:00 | Shenandoah Hornets v Hampden Sydney Tigers | W | 23-7 |
| NCAAF | 2022/10/29 17:00 | Averett Cougars v Shenandoah Hornets | W | 0-45 |
| NCAAF | 2022/10/22 17:00 | Shenandoah Hornets v Randolph Macon Yellow Jackets | L | 21-35 |
| NCAAF | 2022/10/15 17:00 | Shenandoah Hornets v Guilford Quakers | W | 38-35 |
| NCAAF | 2022/10/08 18:00 | Bridgewater Eagles v Shenandoah Hornets | L | 23-17 |
| NCAAF | 2022/10/01 17:00 | Shenandoah Hornets v Ferrum Panthers | W | 20-0 |
| NCAAF | 2022/09/17 17:00 | Maryville Scots v Shenandoah Hornets | W | 29-34 |