Head to Head
| NFL Preseason | 2017/08/31 23:00 | BUF Bills v DET Lions | L | 27-17 |
| NFL Preseason | 2016/09/01 23:30 | DET Lions v BUF Bills | W | 31-0 |
| NFL | 2014/10/05 17:00 | DET Lions v BUF Bills | L | 14-17 |
Home History
| NFL | 2017/12/31 18:00 | GB Packers v DET Lions | W | 11-35 |
| NFL | 2017/12/24 18:00 | DET Lions v CIN Bengals | L | 17-26 |
| NFL | 2017/12/16 21:30 | CHI Bears v DET Lions | W | 10-20 |
| NFL | 2017/12/10 18:00 | DET Lions v TB Buccaneers | W | 24-21 |
| NFL | 2017/12/03 18:00 | DET Lions v BAL Ravens | L | 20-44 |
| NFL | 2017/11/23 17:30 | MIN Vikings v DET Lions | L | 30-23 |
| NFL | 2017/11/19 18:00 | DET Lions v CHI Bears | W | 27-24 |
| NFL | 2017/11/12 18:00 | CLE Browns v DET Lions | W | 24-38 |
Away History
| NFL | 2018/02/02 09:34 | BUF Bills v CAR Panthers | L | 19-25 |
| NFL | 2018/01/07 18:05 | BUF Bills v JAX Jaguars | L | 3-10 |
| NFL | 2017/12/31 21:25 | BUF Bills v MIA Dolphins | W | 22-16 |
| NFL | 2017/12/24 18:00 | BUF Bills v NE Patriots | L | 16-37 |
| NFL | 2017/12/17 18:00 | MIA Dolphins v BUF Bills | W | 16-24 |
| NFL | 2017/12/10 18:00 | IND Colts v BUF Bills | W | 7-13 |
| NFL | 2017/12/03 18:00 | NE Patriots v BUF Bills | L | 23-3 |
| NFL | 2017/11/26 18:00 | BUF Bills v KC Chiefs | W | 16-10 |