Head to Head
| NFL Preseason | 2016/09/01 23:30 | DET Lions v BUF Bills | L | 31-0 |
| NFL | 2014/10/05 17:00 | DET Lions v BUF Bills | W | 14-17 |
Home History
| NFL | 2017/01/01 18:00 | BUF Bills v NY Jets | L | 10-30 |
| NFL | 2016/12/24 18:00 | MIA Dolphins v BUF Bills | L | 34-31 |
| NFL | 2016/12/18 18:00 | CLE Browns v BUF Bills | W | 13-33 |
| NFL | 2016/12/11 18:00 | PIT Steelers v BUF Bills | L | 27-20 |
| NFL | 2016/12/04 21:05 | BUF Bills v LV Raiders | L | 24-38 |
| NFL | 2016/11/27 18:00 | JAX Jaguars v BUF Bills | W | 21-28 |
| NFL | 2016/11/20 18:00 | BUF Bills v CIN Bengals | W | 16-12 |
| NFL | 2016/11/08 01:30 | BUF Bills v SEA Seahawks | L | 25-31 |
Away History
| NFL | 2017/01/08 01:15 | DET Lions v SEA Seahawks | L | 6-26 |
| NFL | 2017/01/02 01:30 | GB Packers v DET Lions | L | 31-24 |
| NFL | 2016/12/27 01:30 | DET Lions v DAL Cowboys | L | 21-42 |
| NFL | 2016/12/18 18:00 | DET Lions v NY Giants | L | 6-17 |
| NFL | 2016/12/11 18:00 | CHI Bears v DET Lions | W | 17-20 |
| NFL | 2016/12/04 18:00 | DET Lions v NO Saints | W | 28-13 |
| NFL | 2016/11/24 17:30 | MIN Vikings v DET Lions | W | 13-16 |
| NFL | 2016/11/20 18:00 | JAX Jaguars v DET Lions | W | 19-26 |