Head to Head
| England Premier League 2 | 2023/01/27 13:00 | Middlesbrough U21 v Southampton U21 | D | 2-2 |
| England Premier League 2 | 2022/10/30 12:00 | Southampton U21 v Middlesbrough U21 | L | 8-1 |
Home History
| Premier League International Cup | 2024/12/18 19:00 | Middlesbrough U21 v Benfica U21 | L | 0-1 |
| England Premier League 2 | 2024/12/13 19:00 | Norwich U21 v Middlesbrough U21 | W | 1-3 |
| England Premier League 2 | 2024/11/29 12:00 | Tottenham U21 v Middlesbrough U21 | L | 6-1 |
| England National League Cup | 2024/11/12 19:00 | Halifax v Middlesbrough U21 | W | 1-4 |
| Premier League International Cup | 2024/11/06 19:00 | Middlesbrough U21 v Borussia M'gladbach U21 | W | 3-2 |
| England Premier League 2 | 2024/11/02 15:00 | Middlesbrough U21 v Nottm Forest U21 | L | 1-4 |
| Premier League International Cup | 2024/10/30 19:00 | Middlesbrough U21 v Lyon U21 | L | 0-1 |
| England Premier League 2 | 2024/10/25 18:00 | Middlesbrough U21 v Aston Villa U21 | W | 4-2 |
Away History
| Premier League International Cup | 2024/12/19 19:00 | Southampton U21 v Sporting U21 | L | 0-5 |
| England Premier League 2 | 2024/12/14 12:00 | Man Utd U21 v Southampton U21 | L | 5-1 |
| Premier League International Cup | 2024/12/10 19:00 | Southampton U21 v Real Sociedad U21 | L | 3-4 |
| England National League Cup | 2024/12/03 19:00 | Aldershot v Southampton U21 | L | 2-1 |
| England Premier League 2 | 2024/11/29 14:00 | Stoke U21 v Southampton U21 | W | 0-3 |
| England U21 Premier League Cup | 2024/11/22 19:00 | Southampton U21 v West Brom U21 | D | 2-2 |
| England National League Cup | 2024/11/12 19:00 | Wealdstone v Southampton U21 | L | 3-1 |
| England U21 Premier League Cup | 2024/11/08 19:00 | Swansea U21 v Southampton U21 | W | 1-2 |