Head to Head
| NFL Preseason | 2024/08/10 17:00 | CHI Bears v BUF Bills | L | 33-6 |
| NFL Preseason | 2023/08/26 17:00 | BUF Bills v CHI Bears | W | 24-21 |
| NFL | 2022/12/24 18:00 | BUF Bills v CHI Bears | W | 35-13 |
| NFL Preseason | 2021/08/21 17:00 | BUF Bills v CHI Bears | W | 41-15 |
| NFL | 2018/11/04 18:00 | CHI Bears v BUF Bills | L | 41-9 |
| NFL Preseason | 2018/08/31 00:00 | BUF Bills v CHI Bears | W | 28-27 |
| NFL | 2014/09/07 17:00 | CHI Bears v BUF Bills | W | 20-23 |
Home History
| NFL Preseason | 2024/08/24 17:00 | CAR Panthers v BUF Bills | L | 31-26 |
| NFL Preseason | 2024/08/17 23:00 | BUF Bills v PIT Steelers | W | 9-3 |
| NFL Preseason | 2024/08/10 17:00 | CHI Bears v BUF Bills | L | 33-6 |
| NFL | 2024/01/21 23:30 | KC Chiefs v BUF Bills | L | 27-24 |
| NFL | 2024/01/15 21:30 | PIT Steelers v BUF Bills | W | 17-31 |
| NFL | 2024/01/08 01:20 | BUF Bills v MIA Dolphins | W | 21-14 |
| NFL | 2023/12/31 18:00 | NE Patriots v BUF Bills | W | 21-27 |
| NFL | 2023/12/24 01:00 | BUF Bills v LA Chargers | W | 24-22 |
Away History
| NFL Preseason | 2024/08/23 00:20 | CHI Bears v KC Chiefs | W | 34-21 |
| NFL Preseason | 2024/08/17 17:00 | CIN Bengals v CHI Bears | W | 3-27 |
| NFL Preseason | 2024/08/10 17:00 | CHI Bears v BUF Bills | W | 33-6 |
| NFL | 2024/01/07 21:25 | CHI Bears v GB Packers | L | 9-17 |
| NFL | 2023/12/31 18:00 | ATL Falcons v CHI Bears | W | 17-37 |
| NFL | 2023/12/24 21:25 | ARZ Cardinals v CHI Bears | W | 16-27 |
| NFL | 2023/12/17 18:00 | CHI Bears v CLE Browns | L | 17-20 |
| NFL | 2023/12/10 18:00 | DET Lions v CHI Bears | W | 13-28 |