Stadium: Schmidt Stadium
| NCAAF | 2023/11/11 17:00 | Moravian Greyhounds v Wilkes Colonels | W | 6-41 |
| NCAAF | 2023/11/04 16:00 | Wilkes Colonels v Catholic Cardinals | L | 35-40 |
| NCAAF | 2023/10/21 17:00 | Susquehanna Crusaders v Wilkes Colonels | L | 34-7 |
| NCAAF | 2023/10/14 16:00 | Wilkes Colonels v Keystone Giants | W | 42-7 |
| NCAAF | 2023/10/07 16:00 | Lycoming Warriors v Wilkes Colonels | W | 35-48 |
| NCAAF | 2023/09/30 16:00 | Wilkes Colonels v Juniata Eagles | W | 63-14 |
| NCAAF | 2023/09/23 20:00 | St John Fisher Cardinals v Wilkes Colonels | L | 29-20 |
| NCAAF | 2023/09/16 16:00 | Wilkes Colonels v Brockport Golden Eagles | L | 7-31 |
| NCAAF | 2023/11/11 18:00 | Utica Pioneers v St John Fisher Cardinals | L | 14-0 |
| NCAAF | 2023/11/04 16:00 | Morrisville State Mustangs v St John Fisher Cardinals | L | 30-15 |
| NCAAF | 2023/10/28 16:00 | St John Fisher Cardinals v Alfred Saxons | W | 30-12 |
| NCAAF | 2023/10/21 16:00 | St John Fisher Cardinals v Cortland Red Dragons | L | 14-42 |
| NCAAF | 2023/10/14 18:30 | Hartwick Hawks v St John Fisher Cardinals | W | 21-38 |
| NCAAF | 2023/09/30 22:00 | St John Fisher Cardinals v Brockport Golden Eagles | L | 18-35 |
| NCAAF | 2023/09/23 20:00 | St John Fisher Cardinals v Wilkes Colonels | W | 29-20 |
| NCAAF | 2023/09/16 17:00 | Keystone Giants v St John Fisher Cardinals | W | 20-35 |