[5] 2 de Mayo 0-0 Cerro Porteno [2] 2025-07-13 20:30
Stadium: Estadio Monumental Rio Parapiti Round: 16
Referee: Blas Romero Home Manager: Marcelo Palau Away Manager: Diego Martinez
Head to Head
| Paraguay Division Profesional | 2025/05/24 22:00 | Cerro Porteno v 2 de Mayo | D | 1-1 |
| Paraguay Division Profesional | 2025/03/23 19:00 | 2 de Mayo v Cerro Porteno | D | 1-1 |
| Paraguay Division Profesional | 2024/09/29 23:30 | Cerro Porteno v 2 de Mayo | W | 0-3 |
| Paraguay Division Profesional | 2024/07/29 23:00 | 2 de Mayo v Cerro Porteno | D | 1-1 |
| Paraguay Division Profesional | 2024/04/20 00:30 | 2 de Mayo v Cerro Porteno | L | 0-2 |
| Paraguay Cup | 2019/08/07 22:30 | Cerro Porteno v 2 de Mayo | W | 4-5 |