[5] Orlando City SC 1-2 FC Cincinnati [14] 2021-10-19 10:30
Stadium: Inter&Co Stadium
Referee: Christopher Penso Home Manager: Oscar Pareja Away Manager: Pat Noonan
Head to Head
| USA MLS | 2021/10/16 23:30 | FC Cincinnati v Orlando City SC | W | 0-1 |
| USA MLS | 2021/08/07 23:30 | FC Cincinnati v Orlando City SC | D | 1-1 |
| USA MLS | 2021/05/01 23:30 | Orlando City SC v FC Cincinnati | W | 3-0 |
| USA MLS | 2019/09/29 21:00 | FC Cincinnati v Orlando City SC | D | 1-1 |
| USA MLS | 2019/05/19 19:00 | Orlando City SC v FC Cincinnati | W | 5-1 |