Vendsyssel Håndbold was a handball club from Frederikshavn, Denmark. Vendssysel Håndbold played on Frederikshavn FI's license and competed in the women's Danish 1st Division until February 2022. The home arena of the club was DRINX Arena in a small town, outside of Sæby, called Syvsten. It was founded on 11 May 2011.
When the team was founded, they started in the third tier, the 2nd Division. In their first season they finished 2nd, which qualified them for the promotion playoff. They did however lose to Tarm-Foersum Håndbold. Despite that they were promoted when IF Stjernen pulled their team from the 1st Division. The team hired former Danish national team coach Lars Rasmussen.
In the 2019-2020 season, Vendsyssel were leading the 1st Division after 19 games with 17 wins, 1 draw and a loss. This was when the Danish Danish Handball Federation decided to cancel the season with 3 matches to go due to the COVID-19 pandemic. Vendsyssel Håndbold was named the winner of the 1st Division and was promoted to the top league.
In the following season they were however relegated when they finished last in the regular season.
It was announced in February 2022, that the club had filed for bankruptcy and the players contracts would be dissolved. The team's placement and points in the Danish 1st Division would also be cancelled. The club's licence was thus handed over to the parent club Frederikshavn FI, which was also relegated to the 3rd division in the 2022/23 season.