| NCAAF | 11/03 16:00 | 1 | Ohio Dominican Panthers v Kentucky Wesleyan | L | 65-7 | |
| NCAAF | 10/27 17:00 | 1 | Hillsdale Chargers v Kentucky Wesleyan | L | 34-0 | |
| NCAAF | 10/20 18:00 | 1 | Kentucky Wesleyan v Lake Erie | W | 46-6 | |
| NCAAF | 10/13 20:00 | 1 | Tiffin Dragons v Kentucky Wesleyan | L | 43-17 | |
| NCAAF | 09/29 18:00 | 1 | Kentucky Wesleyan v Walsh U. Cavaliers | L | 17-23 | |
| NCAAF | 09/22 18:00 | 1 | Kentucky Wesleyan v Malone University Pioneers | W | 44-38 | |
| NCAAF | 09/15 23:00 | 1 | Kentucky Wesleyan v Kentucky Thorobreds | W | 19-13 | |
| NCAAF | 09/08 18:00 | 1 | Quincy v Kentucky Wesleyan | L | 31-24 | |
| NCAAF | 09/01 18:00 | 1 | Kentucky Wesleyan v Findlay Oilers | L | 19-69 | |
| NCAAF | 08/31 23:00 | 1 |
Murray State
v
Kentucky Wesleyan |
L | 67-7 |
Kentucky Wesleyan College's American football team, known as the Panthers, is a proud and competitive program representing the institution in collegiate football. Based in Owensboro, Kentucky, the team competes at the NCAA Division II level and is a member of the Great Midwest Athletic Conference (G-MAC). The Panthers are known for their strong work ethic, team spirit, and commitment to excellence both on and off the field. With a rich history of developing talented athletes and fostering community pride, Kentucky Wesleyan's football team strives to achieve success through disciplined play, strategic coaching, and a dedication to student-athlete growth.