Head to Head
| NFL | 2021/01/09 18:05 | IND Colts v BUF Bills | L | 24-27 |
| NFL Preseason | 2019/08/08 23:00 | IND Colts v BUF Bills | L | 16-24 |
| NFL | 2018/10/21 17:00 | BUF Bills v IND Colts | W | 5-37 |
| NFL | 2017/12/10 18:00 | IND Colts v BUF Bills | L | 7-13 |
| NFL Preseason | 2016/08/13 23:00 | BUF Bills v IND Colts | W | 18-19 |
| NFL | 2015/09/13 17:00 | BUF Bills v IND Colts | L | 27-14 |
Home History
| NFL Preseason | 2021/08/27 23:00 | IND Colts v DET Lions | W | 27-17 |
| NFL Preseason | 2021/08/22 00:00 | IND Colts v MIN Vikings | W | 12-10 |
| NFL Preseason | 2021/08/15 17:00 | CAR Panthers v IND Colts | W | 18-21 |
| NFL | 2021/01/09 18:05 | IND Colts v BUF Bills | L | 24-27 |
| NFL | 2021/01/03 21:25 | JAX Jaguars v IND Colts | W | 14-28 |
| NFL | 2020/12/27 18:00 | IND Colts v PIT Steelers | L | 24-28 |
| NFL | 2020/12/20 18:00 | HOU Texans v IND Colts | W | 20-27 |
| NFL | 2020/12/13 21:05 | IND Colts v LV Raiders | W | 44-27 |
Away History
| NFL Preseason | 2021/08/28 17:00 | GB Packers v BUF Bills | W | 0-19 |
| NFL Preseason | 2021/08/21 17:00 | BUF Bills v CHI Bears | W | 41-15 |
| NFL Preseason | 2021/08/13 23:00 | BUF Bills v DET Lions | W | 16-15 |
| NFL | 2021/01/24 23:40 | BUF Bills v KC Chiefs | L | 24-38 |
| NFL | 2021/01/17 01:15 | BAL Ravens v BUF Bills | W | 3-17 |
| NFL | 2021/01/09 18:05 | IND Colts v BUF Bills | W | 24-27 |
| NFL | 2021/01/03 18:00 | MIA Dolphins v BUF Bills | W | 26-56 |
| NFL | 2020/12/29 01:15 | BUF Bills v NE Patriots | W | 38-9 |