[4] Northampton 1-0 Leyton Orient [8] 2021-08-09 15:00
Stadium: Sixfields Stadium Round: 19
Referee: Andrew Kitchen Home Manager: Jon Brady Away Manager: Kenneth Francis Jackett
Head to Head
| Club Friendly List | 2020/08/22 12:00 | Northampton v Leyton Orient | W | 1-0 |
| England League 2 | 2020/01/21 19:45 | Leyton Orient v Northampton | D | 1-1 |
| England League 2 | 2019/10/05 14:00 | Northampton v Leyton Orient | L | 0-1 |
| England League 2 | 2016/02/13 15:00 | Leyton Orient v Northampton | W | 0-4 |
| England League 2 | 2015/09/26 14:00 | Northampton v Leyton Orient | D | 1-1 |
| England EFL Trophy | 2014/11/11 19:45 | Leyton Orient v Northampton | L | 2-0 |
| Club Friendly List | 2014/07/26 14:00 | Northampton v Leyton Orient | L | 0-1 |
Home History
| England League 2 | 2021/08/07 14:00 | Northampton v Port Vale | W | 1-0 |
| Club Friendly List | 2021/07/31 14:00 | Cambridge Utd v Northampton | D | 0-0 |
| Club Friendly List | 2021/07/24 14:00 | Northampton v Birmingham | W | 3-2 |
| Club Friendly List | 2021/07/17 11:00 | Stamford v Northampton | L | 2-1 |
| Club Friendly List | 2021/07/13 18:00 | Northampton v West Ham | L | 1-2 |
| UK Friendlies | 2021/07/13 18:00 | Northampton v West Ham XI | L | 1-2 |
| England League 1 | 2021/05/09 11:00 | Sunderland v Northampton | D | 1-1 |
| England League 1 | 2021/05/01 14:00 | Northampton v Blackpool | L | 0-3 |
Away History
| England League 2 | 2021/08/07 14:00 | Salford City v Leyton Orient | D | 1-1 |
| Club Friendly List | 2021/07/31 13:00 | Leyton Orient v Gillingham | W | 2-0 |
| Club Friendly List | 2021/07/24 14:00 | Maidenhead Utd v Leyton Orient | W | 1-2 |
| Elite Club Friendlies | 2021/07/17 14:00 | Leyton Orient v Tottenham | D | 1-1 |
| Elite Club Friendlies | 2021/07/13 18:00 | Leyton Orient v West Ham | D | 0-0 |
| UK Friendlies | 2021/07/13 18:00 | Leyton Orient v West Ham XI | D | 0-0 |
| Club Friendly List | 2021/07/06 16:00 | Dundee v Leyton Orient | L | 3-0 |
| England League 2 | 2021/05/08 15:00 | Salford City v Leyton Orient | L | 3-0 |