[4] Northampton 1-0 Leyton Orient [8] 2021-08-06 07:00
Stadium: Sixfields Stadium Round: 19
Referee: Andrew Kitchen Home Manager: Jon Brady Away Manager: Kenneth Francis Jackett
Head to Head
| Club Friendly List | 2020/08/22 12:00 | Northampton v Leyton Orient | W | 1-0 |
| England League 2 | 2020/01/21 19:45 | Leyton Orient v Northampton | D | 1-1 |
| England League 2 | 2019/10/05 14:00 | Northampton v Leyton Orient | L | 0-1 |
| England League 2 | 2016/02/13 15:00 | Leyton Orient v Northampton | W | 0-4 |
| England League 2 | 2015/09/26 14:00 | Northampton v Leyton Orient | D | 1-1 |
| England EFL Trophy | 2014/11/11 19:45 | Leyton Orient v Northampton | L | 2-0 |
| Club Friendly List | 2014/07/26 14:00 | Northampton v Leyton Orient | L | 0-1 |