[15] Southampton 0-1 Wolverhampton [16] 2021-07-03 23:00
Stadium: St. Mary's Stadium Round: 6
Referee: Andrew Madley Home Manager: Ralph Hasenhuttl Away Manager: Bruno Lage
Head to Head
| England Premier League | 2021/02/14 12:00 | Southampton v Wolverhampton | L | 1-2 |
| England FA Cup | 2021/02/11 17:30 | Wolverhampton v Southampton | W | 0-2 |
| England Premier League | 2020/11/23 20:00 | Wolverhampton v Southampton | D | 1-1 |
| England Premier League | 2020/01/18 15:00 | Southampton v Wolverhampton | L | 2-3 |
| England Premier League | 2019/10/19 14:00 | Wolverhampton v Southampton | D | 1-1 |
| England Premier League | 2019/04/13 14:00 | Southampton v Wolverhampton | W | 3-1 |
| England Premier League | 2018/09/29 14:00 | Wolverhampton v Southampton | L | 2-0 |
| England EFL Cup | 2017/08/23 18:45 | Southampton v Wolverhampton | L | 0-2 |
Home History
| England Premier League | 2021/05/23 15:00 | West Ham v Southampton | L | 3-0 |
| England Premier League | 2021/05/18 17:00 | Southampton v Leeds | L | 0-2 |
| England Premier League | 2021/05/15 14:00 | Southampton v Fulham | W | 3-1 |
| England Premier League | 2021/05/11 19:15 | Southampton v Crystal Palace | W | 3-1 |
| England Premier League | 2021/05/08 19:15 | Liverpool v Southampton | L | 2-0 |
| England Premier League | 2021/04/30 19:00 | Southampton v Leicester | D | 1-1 |
| England Premier League | 2021/04/21 17:00 | Tottenham v Southampton | L | 2-1 |
| England FA Cup | 2021/04/18 17:30 | Leicester v Southampton | L | 1-0 |
Away History
| England Premier League | 2021/05/23 15:00 | Wolverhampton v Man Utd | L | 1-2 |
| England Premier League | 2021/05/19 17:00 | Everton v Wolverhampton | L | 1-0 |
| England Premier League | 2021/05/16 13:05 | Tottenham v Wolverhampton | L | 2-0 |
| England Premier League | 2021/05/09 11:00 | Wolverhampton v Brighton | W | 2-1 |
| England Premier League | 2021/05/03 17:00 | West Brom v Wolverhampton | D | 1-1 |
| England Premier League | 2021/04/25 11:00 | Wolverhampton v Burnley | L | 0-4 |
| England Premier League | 2021/04/17 19:15 | Wolverhampton v Sheff Utd | W | 1-0 |
| England Premier League | 2021/04/09 19:00 | Fulham v Wolverhampton | W | 0-1 |