| NCAAF | 11/15 18:00 | 1 | Carson–Newman Eagles v Tusculum Pioneers | L | 26-0 | |
| NCAAF | 11/08 19:00 | 1 | Tusculum Pioneers v Wingate Bulldogs | L | 10-56 | |
| NCAAF | 11/01 18:00 | 1 | Tusculum Pioneers v Mars Hill Lions | L | 7-28 | |
| NCAAF | 10/25 22:00 | 1 | Catawba College v Tusculum Pioneers | L | 38-3 | |
| NCAAF | 10/11 18:00 | 1 | Tusculum Pioneers v Newberry Wolves | L | 28-35 | |
| NCAAF | 09/27 18:00 | 1 | Virginia Wise Highland Cavaliers v Tusculum Pioneers | L | 35-21 | |
| NCAAF | 09/20 18:00 | 1 | Tusculum Pioneers v Emory And Henry Wasps | L | 13-34 | |
| NCAAF | 09/13 18:00 | 1 | Anderson Trojans v Tusculum Pioneers | L | 30-0 | |
| NCAAF | 09/06 22:00 | 1 | Tusculum Pioneers v Lenoir Rhyne Bears | L | 7-28 | |
| NCAAF | 08/30 23:00 | 1 | Bluefield State v Tusculum Pioneers | W | 23-49 | |
| NCAAF | 11/16 23:00 | 1 | Catawba College v Tusculum Pioneers | L | 47-15 | |
| NCAAF | 11/09 18:00 | 1 | Tusculum Pioneers v Carson–Newman Eagles | L | 14-56 | |
| NCAAF | 11/02 18:00 | 1 | Virginia Wise Highland Cavaliers v Tusculum Pioneers | L | 35-27 | |
| NCAAF | 10/26 17:00 | 1 | Tusculum Pioneers v Anderson Trojans | W | 30-28 | |
| NCAAF | 10/19 18:30 | 1 | Mars Hill Lions v Tusculum Pioneers | L | 30-3 | |
| NCAAF | 10/12 18:00 | 1 |
Tusculum Pioneers v
Energetyk Row Rybnik
|
L | 21-23 | |
| NCAAF | 10/05 17:00 | 1 | Tusculum Pioneers v Limestone Saints | L | 21-49 | |
| NCAAF | 09/29 19:00 | 1 | Lenoir Rhyne Bears v Tusculum Pioneers | L | 37-23 | |
| NCAAF | 09/21 17:00 | 1 | Tusculum Pioneers v Newberry Wolves | L | 20-50 | |
| NCAAF | 09/07 23:00 | 1 | West Alabama Tigers v Tusculum Pioneers | L | 45-9 | |
| NCAAF | 11/11 21:00 | 1 | Tusculum Pioneers v Lenoir Rhyne Bears | L | 7-48 | |
| NCAAF | 11/04 17:00 | 1 | Tusculum Pioneers v Mars Hill Lions | W | 29-27 | |
| NCAAF | 10/28 17:00 | 1 | Erskine Flying Fleet v Tusculum Pioneers | W | 14-52 | |
| NCAAF | 10/21 17:00 | 1 | Emory And Henry Wasps v Tusculum Pioneers | L | 27-24 | |
| NCAAF | 10/14 18:00 | 1 | Tusculum Pioneers v Virginia Wise Highland Cavaliers | W | 35-7 | |
| NCAAF | 10/07 17:00 | 1 | Carson–Newman Eagles v Tusculum Pioneers | W | 21-27 | |
| NCAAF | 09/30 18:00 | 1 | Tusculum Pioneers v Barton Bulldogs | L | 14-17 | |
| NCAAF | 09/23 20:00 | 1 | Tusculum Pioneers v Catawba College | W | 35-21 | |
| NCAAF | 09/16 22:00 | 1 | Wingate Bulldogs v Tusculum Pioneers | W | 21-23 | |
| NCAAF | 09/09 18:00 | 1 | Virginia State Trojans v Tusculum Pioneers | L | 21-17 |
The Tusculum Pioneers are a collegiate American football team representing Tusculum University in Greeneville, Tennessee. Competing in the NCAA Division II, the Pioneers are known for their rich history, competitive spirit, and dedication to excellence on the gridiron. The team proudly carries the legacy of pioneering spirit, emphasizing teamwork, discipline, and resilience. With a passionate fan base and a commitment to developing student-athletes both on and off the field, the Tusculum Pioneers strive to achieve success in their conference and uphold the proud traditions of their university.