| NCAAF | 09/28 17:00 | 1 | Newberry Wolves v Tusculum Pioneers | L | 30-20 | |
| NCAAF | 09/21 17:00 | 1 | Limestone Saints v Tusculum Pioneers | W | 10-38 | |
| NCAAF | 09/14 22:00 | 1 | Tusculum Pioneers v West Alabama Tigers | L | 14-47 | |
| NCAAF | 09/06 00:00 | 1 | Delta State v Tusculum Pioneers | L | 24-10 | |
| NCAAF | 11/10 20:00 | 1 | Wingate Bulldogs v Tusculum Pioneers | L | 16-12 | |
| NCAAF | 11/03 17:30 | 1 |
VMI
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Tusculum Pioneers |
L | 20-11 | |
| NCAAF | 10/27 17:30 | 1 | Tusculum Pioneers v Carson–Newman Eagles | W | 41-28 | |
| NCAAF | 10/20 17:30 | 1 | Catawba College v Tusculum Pioneers | L | 55-37 | |
| NCAAF | 10/13 19:00 | 1 | Tusculum Pioneers v Newberry Wolves | W | 14-0 | |
| NCAAF | 10/06 17:30 | 1 | Mars Hill Lions v Tusculum Pioneers | W | 28-31 | |
| NCAAF | 09/29 22:00 | 1 | Lenoir Rhyne Bears v Tusculum Pioneers | L | 35-10 | |
| NCAAF | 09/14 23:00 | 1 | Tusculum Pioneers v Limestone Saints | W | 37-10 | |
| NCAAF | 09/08 17:00 | 1 | Shorter v Tusculum Pioneers | W | 14-61 | |
| NCAAF | 08/30 23:00 | 1 | Tusculum Pioneers v North Greenville Crusaders | L | 3-13 |
The Tusculum Pioneers are a collegiate American football team representing Tusculum University in Greeneville, Tennessee. Competing in the NCAA Division II, the Pioneers are known for their rich history, competitive spirit, and dedication to excellence on the gridiron. The team proudly carries the legacy of pioneering spirit, emphasizing teamwork, discipline, and resilience. With a passionate fan base and a commitment to developing student-athletes both on and off the field, the Tusculum Pioneers strive to achieve success in their conference and uphold the proud traditions of their university.